A New Perspective
نویسندگان
چکیده
In the feline model, retinal detachment initiates a cascade of changes that include photoreceptor-cell “deconstruction,” apoptotic death of some photoreceptors, neurite outgrowth from secondand third-order neurons, remodeling of photoreceptor synaptic terminals, and Müller-cell gliosis. We have previously shown that reattachment within 24 h halts or reverses many of these presumed detrimental changes. However, in patients with retinal detachments, reattachment cannot always be performed within this 24-h window. Moreover, recovery of vision following successful reattachment surgery in the macula is often imperfect. Here, we examine the ability of relatively long-term reattachment (28 d) to stop or reverse several cellular events that occur at 3 d of detachment. In contrast to earlier studies of reattachment, which focused on the regeneration of outer segments, we focus our attention here on other cellular events such as neuronal remodeling and gliosis. Some of these changes are reversed by reattachment, but reattachment itself appears to stimulate other changes that are not associated with detachment. The implications of these events for the return of vision are unknown, but they do indicate that simply reattaching the retina does not return the retina to its pre-detachment state within 28 d. Index Entries: Retinal detachment; retinal reattachment; Müller cell; photoreceptor; rod; cone; neurite outgrowth; epiretinal membrane; gliosis. Received 6/3/03; Accepted 6/6/03. * Author to whom all correspondence and reprint requests should be addressed. E-mail: [email protected]
منابع مشابه
New Health Technologies: A UK Perspective; Comment on “Providing Value to New Health Technology: The Early Contribution of Entrepreneurs, Investors, and Regulatory Agencies”
New health technologies require development and evaluation ahead of being incorporated into the patient care pathway. In light of the recent publication by Lehoux et al who discuss the role of entrepreneurs, investors and regulators in providing value to new health technologies, we summarise the processes involved in making new health technologies available for use in the United Kingdom.
متن کاملA Safety-II Perspective on Organisational Learning in Healthcare Organisations; Comment on “False Dawns and New Horizons in Patient Safety Research and Practice”
In their recent editorial Mannion and Braithwaite provide an insightful critique of traditional patient safety improvement efforts, and offer a powerful alternative vision based on Safety-II thinking that has the potential to radically transform the way we approach patient safety. In this commentary, I explore how the Safety-II perspective points to new directions for organisational learning in...
متن کاملComparative Assessment of New Curriculum Development of Restorative Dentistry with Old Curriculum Development From The Perspective Of Faculty Members Of Selected Iranian Universities
Background: Restorative dentistry is an important branch of dentistry and therefore it is very important to train students that have all or the majority of the skills to start practice. The aim of this study was to compare new and old curricula of restorative lessons form the perspective of faculty members of selected Iranian universities. Methods: The perspectives and viewpoints of the faculty...
متن کاملA new perspective to the Mazur-Ulam problem in $2$-fuzzy $2$-normed linear spaces
In this paper, we introduce the concepts of $2$-isometry, collinearity, $2$%-Lipschitz mapping in $2$-fuzzy $2$-normed linear spaces. Also, we give anew generalization of the Mazur-Ulam theorem when $X$ is a $2$-fuzzy $2$%-normed linear space or $Im (X)$ is a fuzzy $2$-normed linear space, thatis, the Mazur-Ulam theorem holds, when the $2$-isometry mapped to a $2$%-fuzzy $2$-normed linear space...
متن کاملHypertonicity in Children with Cerebral Palsy: A New Perspective
Objectives: Hypertonicity is a major problem in children with cerebral palsy that has not been explained effectively to address clinical decision making. Therefore, this article aims to provide a theoretical framework about hypertonicity for clinicians, rehabilitation and medical practitioners to be used in their practice. Methods: Literature was reviewed to examine the new perspectives towa...
متن کامل